| Type | Conference Documentation |
ISBN | 1-59430-114-X |
Publication Date | November, 2005 |
| Number of Pages | |
List Price | $299 |
Availability | In Stock |
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RELATED TITLES
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Overview
Conference Partners
Journal of Micromechanics and Microengineering
MEMS Manufacturing
NanoSciences, Inc.
The 7th meeting in our MEMS Series including BioMEMS and COTS MEMS is aimed at an in-depth idea exchange between the established MEMS industry and commercialization infrastructure looking for its expansion to new segments of the MEMS marketplace. Presenters from around the globe will provide the latest data on cutting-edge technologies with an array of novel market-ready biological, medical, diagnostic, optical and other MEMS-based devices, and micro- and nanosystems seeking to find their path to commercialization. • Infrastructure Development for Design, Manufacturing
• System Integration Challenges / System-on-a-Chip
• Sensing, Detection, & Identification with MEMS, BioMEMS, Micro/Nano Systems
• Bioengineered and Bioinspired Micro & NanoSystems
• Biochips, Biosensors, Micro & Nanofluidics
• Microdevices for Biomedical Engineering
• Universal Standards for MEMS across Diverse ApplicationsThis meeting is conveniently-timed with the 3rd International Conference "Photonic NanoSystems 2005" which will take place at the same venue on November 7- 8, 2005.
Table of Contents
Tuesday, November 8, 2005 1:15 Registration, Exhibit/Poster Setup, Refreshments 1:55 Welcome and Opening Remarks MEMS, BIOMEMS & MICRO/NANO
SYSTEMS FOR SENSING, DETECTION,
IDENTIFICATION & ANALYSIS 2:00 BioMEMS and Real-World Bioassays (Review)
Raymond P. Mariella, Jr., PhD, Director, Center for Micro and Nanotechnology, Lawrence Livermore National Laboratory
Microtechnology has matured to the point where commercial laboratory instrumentation employs microfluidics and related microfabricated systems in biological and medical instrumentation, today, based not on novelty but rather on performance, in general or in specific applications. Part of this is the ability to integrate more than a single function on a relatively small microfluidic card. Beyond this, new capabilities in Microfluidics and Microtechnology are now emerging that enable such disparate applications as “reagentless assays” and reagent production!! This talk will review important aspects of BioMEMS. This work was performed under the auspices of the U.S. Department of Energy by University of California Lawrence Livermore National Laboratory under contract No. W-7405-Eng-48. 2:45 Electric Field Assembly of DNA Nanostructures and New Quantum Dot Biosensor Devices
Michael J. Heller, PhD, Professor, Depts of Bioengineering/Electrical and Computer Engineering, University California - San Diego
It is difficult using present nanofabrication methods to modify in precise ways or assemble nanostructures such as quantum dots, photonic crystals or metal nanoparticles into viable higher order structures. We are using electric field techniques and active microelectronic array devices to carry out nanoparticle modifications and the assisted selfassembly of nanoparticles into higher order 3-D structures. Modified quantum dots structures are being developed for new biosensor applications. 3:15 The Clinical Application of Nanotechnology-Enabled Molecular Analysis
Vincent Gau, PhD, Co-Founder, CEO, President and CTO, GeneFluidics Inc.
A novel molecular analysis platform based in bionanotechnology and microfluidics will be presented. The platform includes two distinct yet synergistic components-ultra-sensitive electrochemical detection and automated sample preparation microfluidic cartridges. The platformutilizes nanoscale chemical sensor treatments to enable the detection of target genetic material, proteins, and small molecules in raw samples without the use of amplification methods such as PCR. Proprietary microfluidic geometries are simultaneously leveraged in plastic cartridges to drive completely “hands free” molecular detection. 3:45 Refreshment Break, Exhibit/Poster Viewing 4:15 Autonomous Integrated Microsystem for Gene Expression Analysis in Space
Applications
Antonio J. Ricco, PhD, Director, National Center for Space Biological Technologies, Stanford University*
GeneSat-1 is an autonomous culture/genetic analysis system for satellite-based studies of spaceflight effects on gene expression in microorganisms. This payload (mass, volume: ca. 2 kg, 2 L) will carry dormant E. coli into low Earth orbit. The fluidics, comprising a dozen 100-µL culture wells in microwell-plate format, include manifolded inlets/outlets and integral filtration. Blue-LED-excited fluorescence probes expression levels via GFP fusions; optical density measurements normalize results to culture population. Results will be telemetered to Earth.
*In collaboration with: D.Oswell, C.Storment, U.Udoh, Stanford; E.Agasid, V.Barker, T.Fahlen, D.Hinds, J.W.Hines, R.Mancinelli, R.Ricks, K.Ronzano, D.Squires, G.Swaiss, L.Timucin, B.Yost, NASA Ames Research Center; L.Levine, ALine, Inc. 4:45 Combining Microfluidics and Magnetoelectronics for Rapid, Multiplexed Biodetection in Complex Samples
Lloyd J. Whitman, PhD, Head, Surface Nanoscience and Sensor Technology Section, and Shawn P. Mulvaney, PhD, Staff Member, Naval Research Laboratory
The Naval Research Laboratory has developed the compact Bead Array Sensor System (cBASS™) for multiplexed detection of proteins, bacteria, and viruses, including nucleic acids and toxins. cBASS™ uses magnetic microbeads to label biomolecules captured onto a receptor-patterned microchip that contains an embedded array of magnetic microsensors. In addition to serving as reporter labels, the microbeads allow microfluidic force discrimination - an assay innovation that greatly reduces unwanted background signal-enabling the rapid identification of biomolecules with high sensitivity and specificity with little or no sample processing. Highly sensitive multiplexed DNA assays (<10 fM) and immunoassays (<50 pg/mL) have been demonstrated in less than 20 minutes, without amplification or preconcentration steps, using a variety of sample matrices including blood and food products. Products for veterinary, food testing, and environmental markets are under development in partnership with Seahawk Biosystems (Austin, TX). 5:15 Sensor Development for Biological and Chemical Warfare Agents
Josef Hormes, PhD, Director, Center for Advanced Microstructures and Devices (CAMD), Professor Physics Dept, Louisiana State University*
The development of portable and highly sensitive detector system for chemical and biological warfare agents is crucial for military and Homeland Security applications. One of the many challenges in developing these Biosensor systems is the seamless integration of MEMS technologies and biology with high-sensitivity detection and electronics. The sensor presented here is based on functionalized magnetic micro/nano-particles, a Giant Magnetic Resistance (GMR) sensor, an integrated microfluidic system, and a highly selective bio-recognition process. The modular design and small footprint offers a user-friendly and flexible/adaptable biological interface well-suited for further developing a portable Biosensor. Details of MEMS integration with biological active surfaces will be discussed as well as preliminary sensor data presented.
*In Collaboration with: M.Pease, R.Louis, P.Datta, J.Hammacher, C.Liu, and J.Goettert, LSU; M.Tondra, NVE Corporation 5:45 End of Day One Wednesday, November 9, 2005 8:15 Exhibit/Poster Viewing, Coffee and Pastries MEMS, BIOMEMS AND MICRO/NANO
SYSTEMS IN THE REAL WORLD
MARKETPLACE: ISSUES AND SOLUTIONS 9:00 MEMS, BioMEMS and Nanotechnology Today and in The Future
Henrik Hellquist, MD and Helene Andersson, PhD, Silex Microsystems AB, Sweden
As a leading contract manufacturer of customized MEMS and nanotechnology Silex Microsystems develops and produces components that will enhance the next generation biotech and medical devices. We have a wide range of customers in the biomedical field and see a large trend for using new, low-cost, MEMS chips for integration in both invasive and non-invasive disposable medical devices. 9:30 MEMS Industry Issues: 2005
Chris Lumb, CEO, Micralyne Inc, Canada
The MEMS supply has been through much turmoil over the last several years. Many foundries are doing well; however, this hasn’t been the case for the last few years. Does the new optimism in the industry mean that MEMS has really entered the mainstream? Or are there still many challenges ahead? Chris Lumb, CEO of Micralyne Inc will provide a perspective on what lies ahead for the industry. 10:00 Microsystem Technologies for GE Applications
Wei-Cheng Tian, PhD, Microsystems & Microfluidics Lab, Micro & Nano Structures Technology Center, GE Global Research Center, General Electric Company
MEMS and microsystem technologies are becoming key enablers to a broad range of industrial, infrastructure, healthcare, and homeland security applications for GE. This talk will present an overview of the GE microsystem applications space and how it drives our research, development, and commercialization on microsystem technologies. The speaker will also highlight several ongoing microsystem programs for applications such as gas sensing, medical diagnostics, non-destructive evaluation, and chem/bio sensing applications. 10:30 Refreshment Break, Exhibit/Poster Viewing BIOENGINEERED AND BIOINSPIRED
MICRO AND NANOSYSTEMS 11:00 Biological Large Scale Integration
Stephen Quake, PhD, Professor, Dept of Bioengineering, Stanford University
The integrated circuit revolution changed our lives by automating computational tasks on a grand scale. Our group has been asking whether a similar revolution could be enabled by automating biological tasks. To that end, we have developed a method of fabricating very small plumbing devices - chips with small channels and valves that manipulate fluids containing biological molecules and cells, instead of the more familiar chips with wires and transistors that manipulate electrons. Using this technology, we have fabricated chips that have thousands of valves in an area of one square inch. We are using these chips in applications ranging from screening to structural genomics to ultrasensitive genetic analysis. However, there is also a substantial amount of basic physics to explore with these systems - the properties of fluids change dramatically as the working volume is scaled from milliliters to nanoliters. 11:30 Multiwalled Carbon Nanotubes: Interconnecting Solid-state Electronics with Biosystems
Alan M. Cassell, PhD, Project Scientist, Center for Nanotechnology, NASA Ames Research Center
Multiwalled carbon nanotubes (MWNTs) are essentially highly conductive metallic wires with extremely high aspect ratios. Vertically aligned MWNTs can be grown directly on prefabricated electronic circuits with the nanoscale precision. Such materials are ideal metallic wires to interconnect solid-state electronics and biosystems. We demonstrate the advantage of this system in two studies. First, inlaid MWNT nanoelectrode arrays directly link underlying circuits with an extremely small amount of DNA molecules are demonstrated as an ultrasensitive electronic DNA sensor. Second, multiplex MWNT nanoelectrode arrays are employed for developing a closed-loop implanted device for electrical stimulating and recording.
*In collaboration with: J.Li, T.-D.B.Nguyen-Vu, H.Chen, J.Koehne, R.Andrews, M.Meyyappan 12:00 What Makes BioMEMS Superior?
Holger Bartos, PhD, and Ralf-Peter Peters, PhD, Boehringer Ingelheim microParts, Germany
Recent developments in fluidics, microelectronics and detection techniques have matured the use of BioMEMS in medical diagnostics and drug discovery. Microfluidic chips, for example, now compete in routine applications with macroscale test devices. It has become obvious that miniaturisation alone is not the key factor for success. The recent trend in microfluidics has been the development of integrated devices which incorporate multiple fluidic assay functions like blood separation, metering, resuspension, fluid transport and detection. In this presentation it is discussed how design, function, fabrication and application have an impact on the technical and commercial success of BioMEMS. 12:30 Luncheon Sponsored by Wohlers & Tan
Marketing & Communication for the Sciences 2:00 From Modeling to Design – Creating Customized Lateral Advection in Microchannels
Peter Howell, PhD, Research Chemist, Center for Biomolecular Science and Engineering, Naval Research Laboratory
For the first time, an algorithm was developed that could evaluate microfluidic designs faster than could be done experimentally. Designs were evaluated at a rate of 106 / hour, and optimized for a chosen behavior. This allowed us to build microfluidic mixers able to achieve superior mixing in less than half the space of previous designs. Other applications include separations, detection, microarrays, surface patterning, and cytometry, which was also demonstrated. 2:30 Marker Specific Enrichment of Rare Cells Using Dielectrophoresis
Hyongsok (Tom) Soh, PhD, Professor, Dept of Mechanical Engineering and Biomolecular Science & Engineering Program, University of California – Santa Barbara
Current techniques in high speed cell sorting are limited by the inherent coupling among three competing parameters of performance - throughput, purity and rare cell recovery. Microfluidics provides an alternate strategy to decouple these parameters through arrayed devices that operate in parallel. Towards this end, an affinity-based enrichment of rare bacteria expressing a specific surface marker using dielectrophoresis is presented, and we demonstrate over 200-fold enrichment at 10,000 cells/channel/sec. 3:00 Characterization of In-Plane Pneumatically-Actuated PDMS Membranes for Microfluidics
S.J. Lee, PhD, Professor and C.Y. Chan, Dept of Mechanical and Aerospace Engineering, San José State University;
N. Sundararajan, PhD, Staff Scientist, Biomedical and Life Sciences, Digital Health Group, Intel Corporation*
This work presents characterization of the lateral deflection of polydimethylsiloxane (PDMS) membranes under pneumatic actuation. A brief review of prior work that demonstrated microfluidic operations using single-mask soft lithography will be presented followed by recent experimental measurements to quantitatively relate geometric parameters and applied pressure to the output displacement of an in-plane microvalve seat. Design and fabrication issues for thin-wall boundaries and their edge constraints are discussed and examined with SEM imaging.
*In collaboration with: T.Tam, Intel; and K.Van, Genus, Inc. 3:30 Refreshment Break, Exhibit/Poster Viewing 4:00 Cellular Analysis in Multiwell Plates with Integrated Microfluidic Perfusion System
Karel Domansky, PhD, Research Scientist, Biological Engineering Division & Biotechnology Process Engineering Center, Massachusetts Institute of Technology
A new cell culture system has been developed. It is based on standard multiwell cell culture plate format but it provides perfused three-dimensional cell culture capability. The new capability is achieved by integrating microfluidic valves, pumps, and capacitors into the plate. The system provides a means to conduct high throughput cellular analysis for toxicology and metabolism. It can be used as a model for human diseases, exposure-related pathologies, and cancer. 4:30 Microfabricated Fluorescence-Activated Cell Sorter for Single Cell Handling and Manipulation
Jun Keun Chang, PhD, Assistant Professor, School of Mechanical and Aerospace Engineering, Seoul National University; and CEO, Digital Bio Technology, Korea*
This presentation covers: 1) a novel flow manipulation and particle detection method for microfabricated fluorescenceactivated cell sorter (µFACS), and 2) micro chip type-flow cytometry. Using the nozzle flow in a micro channel, we have achieved the ability to control and sort cells via a hydrodynamic flow manipulation method. Also, we have developed an online calibration technique for accurate timing between detection and actuation with synchronized image-detection algorithm. Our microchip based-system is so flexible that it can be tuned to any assay conditions with various flow speeds, particle densities and buffer/sample viscosities by real-time calibration.
*In collaboration with: H.Bang, D.-C.Han Seoul National University; K.C.Cho, C.Chung, Digital Bio Technology, Korea 5:00 Development of Cell-Based Microfluidic Systems
Shankar Sundaram, PhD, Vice President, Biomedical Technology, CFD Research Corporation
The maturation of microfluidics, along with the emergence of nanoprobes and computational systems biology, provides an unprecedented opportunity to understand and exploit cellular response to controlled, external stimuli with far-reaching applications in several fields including, healthcare, defense, as well as environmental monitoring. Successful development of cell-based microfluidic devices poses challenges on three fronts – (a) cell handling and instrumentation (b) probe and assay design, and (c) analysis (after deconvolution) of measured response in the context of the cellular system. This requires an interdisciplinary approach with collaborations between bioengineers, molecular biologists and bionformatics specialists. Common challenges and solution strategies will be demonstrated in the context of ongoing development efforts in our lab, in particular a T-cell-based sensor for defense preparedness, DEP-based cell sorter for biodiagnostics, cellular adhesion and uptake assays for drug discovery and delivery, and microbial power generation from biofuels for energy applications. 5:30 Closing Remarks. End of Conference
(Agenda, times and titles of presentations are subject to change.)
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